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Li S*, Mirlekar B*, Johnson BM, Brickey WJ, Wrobel JA, Yang N, Song D, Entwistle S, Tan X, Deng M, Cui Y, Li W, Vincent BG, Gale M Jr, Pylayeva-Gupta Y#, Ting JP#. (2022) STING-induced regulatory B cells compromise NK function in cancer immunity. *co-first, #co-corresponding. Nature. Pubmed

Mirlekar B, Wang Y, Li S, Zhou M, Entwistle S, De Buysscher T, Morrison A, Herrera G, Harris C, Vincent BG, Ting JP, Rashid N, Kim WY, Yeh JJ, Pylayeva-Gupta Y. (2022) Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity. Cell Reports Medicine. Pubmed

Joiner JB*, Kren NP*, Durham PG, McRee AJ, Dayton PA, Pylayeva-Gupta Y. (2022) Low-Intensity Focused Ultrasound Produces Immune Response in Pancreatic Cancer. Ultrasound Med Biol. * co-first authors. Pubmed

Rojas J, Joiner J, Velasco B, Bautista K, Aji A, Moore C, Beaumont N, Pylayeva-Gupta Y, Dayton P, Gessner R, Czernuszewicz T. (2022) Validation of a Combined Ultrasound and Bioluminescence Imaging System with Magnetic Resonance Imaging in Orthotopic Pancreatic Murine Tumors. Sci Reports. Pubmed

Michaud D, Mirlekar B, Steward C, Bishop G, Pylayeva-Gupta Y. (2022) B Cell Receptor Signaling and Protein Kinase D2 Support Regulatory B Cell Function in Pancreatic Cancer. Front Immunol. Pubmed

Mirlekar B, Michaud D, Pylayeva-Gupta Y. (2021) IL-35 Detection in B Cells at the mRNA and Protein Level. Methods Mol Biol. Pubmed


Mirlekar B, Pylayeva-Gupta Y. (2021) IL-12 Family Cytokines in Cancer and Immunotherapy. Cancers. Pubmed


Michaud D, Steward CR, Mirlekar B, Pylayeva-Gupta Y. (2020) Regulatory B cells in cancer. Immunol Rev. Pubmed


Joiner JB, Pylayeva-Gupta Y, Dayton PA. (2020) Focused Ultrasound for Immunomodulation of the Tumor Microenvironment. J Immunology. 205(9):2327-2341. Pubmed

Kren N, Michaud D, Bagchi S, Greene K, Pylayeva-Gupta Y. (2020) Rab27a plays a dual role in metastatic propensity of pancreatic cancer. Sci Rep. 10(1):7390. Pubmed

Pylayeva-Gupta Y. (2020) Pancreatic Cancer Thrives on Hijacking a Homeostatic Tissue Repair Pathway. Gastroenterology. 158(5):1216-1218. Pubmed

Mirlekar B, Michaud D, Lee SJ, Kren NP, Harris C, Greene K, Goldman EC, Gupta GP, Fields RC, Hawkins WG, DeNardo DG, Rashid NU, Yeh JJ, McRee AJ, Vincent BG, Vignali DAA, Pylayeva-Gupta Y. (2020) B cell-Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer. Cancer Immunol Res. 8(3):292-308. Pubmed

Ma X, Shou P, Smith C, Chen Y, Du H, Sun C, Porterfield Kren N, Michaud D, Ahn S, Vincent B, Savoldo B, Pylayeva-Gupta Y, Zhang S, Dotti G, Xu Y. (2020) Interleukin-23 engineering improves CAR T cell function in solid tumors. Nat Biotechnology. 38(4):448-459. Pubmed

Michaud D, Mirlekar B, Bischoff S, Cowley DO, Vignali DAA, Pylayeva-Gupta Y. (2020) Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3. Cytokine. 125:154817. Pubmed




Du H, Hirabayashi K, Ahn S, Kren NP, Montgomery SA, Wang X, Tiruthani K, Mirlekar B, Michaud D, Greene K, Herrera SG, Xu Y, Sun C, Chen Y, Ma X, Ferrone CR, Pylayeva-Gupta Y, Yeh JJ, Liu R, Savoldo B, Ferrone S, Dotti G. (2019) Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells. Cancer Cell. 35(2):221-237. Pubmed

Mirlekar B, Michaud D, Searcy R, Greene K, Pylayeva-Gupta Y. (2018) IL35 Hinders Endogenous Antitumor T-cell Immunity and Responsiveness to Immunotherapy in Pancreatic Cancer. Cancer Immunol Res. 6(9):1014-1024. Pubmed


Pylayeva-Gupta Y. (2016) Molecular Pathways: Interleukin-35 in Autoimmunity and Cancer. Clin Cancer Res. 22(20):4973-4978. Epub 2016 Aug 31. Pubmed

Zeitouni D, Pylayeva-Gupta Y, Der CJ, Bryant KL. (2016) KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment.Cancers (Basel). 8(4). pii: E45. doi: 10.3390/cancers8040045. Review. Pubmed


Pylayeva-Gupta Y, Das S, Handler JS, Hajdu CH, Coffre M, Koralov SB, Bar-Sagi D. (2016) IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia. Cancer Discov. 6(3):247-55. Pubmed


Grabocka E, Pylayeva-Gupta Y, Jones MJ, Lubkov V, Yemanaberhan E, Taylor L, Jeng HH, Bar-Sagi D. (2014) Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response. Cancer Cell 25(2):243-56. Pubmed


Pylayeva-Gupta Y, Lee KE, Bar-Sagi, D. (2013) Microdissection and Culture of Murine Pancreatic Ductal Epithelial Cells. Methods in Molecular Medicine 980:267-79. Pubmed


Ochi A, Barilla R, Zambirinis C, Fallon N, Rehman A, Pylayeva-Gupta Y, Badar S, Hajdu C, Frey A, Bar-Sagi D, Miller G. (2012) MyD88 Inhibition Amplifies Dendritic Cell Capacity to Promote Pancreatic Carcinogenesis via Th2 cells J. Exp. Med. 209(9): 1671-87. Pubmed


Pylayeva-Gupta Y, Lee KE, Hajdu CH, Miller G, Bar-Sagi D. (2012) Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell 12; 21(6):836-47. Pubmed


Mallen-St Clair J, Soydaner-Azeloglu R, Lee KE, Taylor L, Livanos A, Pylayeva-Gupta Y, Miller G, Margueron R, Reinberg D, Bar-Sagi D. (2012) EZH2 couples pancreatic regeneration to neoplastic progression. Genes Dev. 26(5):439-44. Pubmed


Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D. (2011) RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer 11(11):761-74. Pubmed


Baranwal S, Wang Y, Rathinam R, Lee J, Jin L, McGoey R, Pylayeva Y, Giancotti F, Blobe GC, Alahari SK. (2011) Molecular characterization of the tumor-suppressive function of nischarin in breast cancer. J Natl Cancer Inst. 103(20):1513-28. Pubmed


Pylayeva Y, Gillen KM, Beggs HE, Reichardt LF, Giancotti FG. (2009) Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest. 119(2):252-66. Pubmed


Pylayeva Y, Guo W, Giancotti FG. (2007) Analysis of integrin signaling in genetically engineered mouse models of mammary tumor progression. Methods Enzymol. 426:439-61. Pubmed


Pylayeva Y, Giancotti FG. (2007) Tensin relief facilitates migration. Nat Cell Biol. 9(8):877-9. Pubmed


Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller W, Inghirami G, Giancotti FG. (2006) Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 126(3):489-502. Pubmed


Pylayeva Y, Giancotti FG. (2006) Development requires activation but not phosphorylation of beta1 integrins. Genes Dev. 20(9):1057-60. Pubmed

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