Publications

2020-2021

 

Mirlekar B, Michaud D, Pylayeva-Gupta Y. (2021) IL-35 Detectionn in B Cells at the mRNA and Protein Level. Methods Mol Biol. Pubmed

 

Mirlekar B, Pylayeva-Gupta Y. (2021) IL-12 Family Cytokines in Cancer and Immunotherapy. Cancers. Pubmed

 

Michaud D, Steward CR, Mirlekar B, Pylayeva-Gupta Y. (2020) Regulatory B cells in cancer. Immunol Rev. Pubmed

 

Joiner JB, Pylayeva-Gupta Y, Dayton PA. (2020) Focused Ultrasound for Immunomodulation of the Tumor Microenvironment. J Immunology. 205(9):2327-2341. Pubmed

Kren N, Michaud D, Bagchi S, Greene K, Pylayeva-Gupta Y. (2020) Rab27a plays a dual role in metastatic propensity of pancreatic cancer. Sci Rep. 10(1):7390. Pubmed

Pylayeva-Gupta Y. (2020) Pancreatic Cancer Thrives on Hijacking a Homeostatic Tissue Repair Pathway. Gastroenterology. 158(5):1216-1218. Pubmed

Mirlekar B, Michaud D, Lee SJ, Kren NP, Harris C, Greene K, Goldman EC, Gupta GP, Fields RC, Hawkins WG, DeNardo DG, Rashid NU, Yeh JJ, McRee AJ, Vincent BG, Vignali DAA, Pylayeva-Gupta Y. (2020) B cell-Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer. Cancer Immunol Res. 8(3):292-308. Pubmed

Ma X, Shou P, Smith C, Chen Y, Du H, Sun C, Porterfield Kren N, Michaud D, Ahn S, Vincent B, Savoldo B, Pylayeva-Gupta Y, Zhang S, Dotti G, Xu Y. (2020) Interleukin-23 engineering improves CAR T cell function in solid tumors. Nat Biotechnology. 38(4):448-459. Pubmed

Michaud D, Mirlekar B, Bischoff S, Cowley DO, Vignali DAA, Pylayeva-Gupta Y. (2020) Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3. Cytokine. 125:154817. Pubmed

 

2016-2019

 

Du H, Hirabayashi K, Ahn S, Kren NP, Montgomery SA, Wang X, Tiruthani K, Mirlekar B, Michaud D, Greene K, Herrera SG, Xu Y, Sun C, Chen Y, Ma X, Ferrone CR, Pylayeva-Gupta Y, Yeh JJ, Liu R, Savoldo B, Ferrone S, Dotti G. (2019) Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells. Cancer Cell. 35(2):221-237. Pubmed

Mirlekar B, Michaud D, Searcy R, Greene K, Pylayeva-Gupta Y. (2018) IL35 Hinders Endogenous Antitumor T-cell Immunity and Responsiveness to Immunotherapy in Pancreatic Cancer. Cancer Immunol Res. 6(9):1014-1024. Pubmed

 

Pylayeva-Gupta Y. (2016) Molecular Pathways: Interleukin-35 in Autoimmunity and Cancer. Clin Cancer Res. 22(20):4973-4978. Epub 2016 Aug 31. Pubmed

Zeitouni D, Pylayeva-Gupta Y, Der CJ, Bryant KL. (2016) KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment.Cancers (Basel). 8(4). pii: E45. doi: 10.3390/cancers8040045. Review. Pubmed

 

Pylayeva-Gupta Y, Das S, Handler JS, Hajdu CH, Coffre M, Koralov SB, Bar-Sagi D. (2016) IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia. Cancer Discov. 6(3):247-55. Pubmed

2006-2015

Grabocka E, Pylayeva-Gupta Y, Jones MJ, Lubkov V, Yemanaberhan E, Taylor L, Jeng HH, Bar-Sagi D. (2014) Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response. Cancer Cell 25(2):243-56. Pubmed

 

Pylayeva-Gupta Y, Lee KE, Bar-Sagi, D. (2013) Microdissection and Culture of Murine Pancreatic Ductal Epithelial Cells. Methods in Molecular Medicine 980:267-79. Pubmed

 

Ochi A, Barilla R, Zambirinis C, Fallon N, Rehman A, Pylayeva-Gupta Y, Badar S, Hajdu C, Frey A, Bar-Sagi D, Miller G. (2012) MyD88 Inhibition Amplifies Dendritic Cell Capacity to Promote Pancreatic Carcinogenesis via Th2 cells J. Exp. Med. 209(9): 1671-87. Pubmed

 

Pylayeva-Gupta Y, Lee KE, Hajdu CH, Miller G, Bar-Sagi D. (2012) Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell 12; 21(6):836-47. Pubmed

 

Mallen-St Clair J, Soydaner-Azeloglu R, Lee KE, Taylor L, Livanos A, Pylayeva-Gupta Y, Miller G, Margueron R, Reinberg D, Bar-Sagi D. (2012) EZH2 couples pancreatic regeneration to neoplastic progression. Genes Dev. 26(5):439-44. Pubmed

 

Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D. (2011) RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer 11(11):761-74. Pubmed

 

Baranwal S, Wang Y, Rathinam R, Lee J, Jin L, McGoey R, Pylayeva Y, Giancotti F, Blobe GC, Alahari SK. (2011) Molecular characterization of the tumor-suppressive function of nischarin in breast cancer. J Natl Cancer Inst. 103(20):1513-28. Pubmed

 

Pylayeva Y, Gillen KM, Beggs HE, Reichardt LF, Giancotti FG. (2009) Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest. 119(2):252-66. Pubmed

 

Pylayeva Y, Guo W, Giancotti FG. (2007) Analysis of integrin signaling in genetically engineered mouse models of mammary tumor progression. Methods Enzymol. 426:439-61. Pubmed

 

Pylayeva Y, Giancotti FG. (2007) Tensin relief facilitates migration. Nat Cell Biol. 9(8):877-9. Pubmed

 

Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller W, Inghirami G, Giancotti FG. (2006) Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 126(3):489-502. Pubmed

 

Pylayeva Y, Giancotti FG. (2006) Development requires activation but not phosphorylation of beta1 integrins. Genes Dev. 20(9):1057-60. Pubmed